What is the most important information I should know about XPOVIO?
Your healthcare provider will do blood tests before you start taking XPOVIO, and often during the first 3 months of treatment, and then as needed during treatment to monitor you for side effects.
Your healthcare provider may change your dose of XPOVIO, stop your treatment for a period of time, or completely stop your treatment if you have certain side effects during treatment with XPOVIO.
XPOVIO can cause serious side effects, including:
Common side effects of XPOVIO include:
low red blood cell count (anemia). Symptoms may include tiredness and shortness of breath
shortness of breath
increased blood sugar
changes in body salt and mineral levels in your blood
changes in kidney and liver function blood tests
These are not all of the possible side effects of XPOVIO.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1‑800‑FDA‑10881‑800‑FDA‑1088.
Before taking XPOVIO, tell your healthcare provider about all of your medical conditions, including if you:
have or have had a recent or active infection
have or have had bleeding problems
are pregnant or plan to become pregnant. XPOVIO can harm your unborn baby
are taking prescription and over-the-counter medicines, vitamins, and herbal supplements
Ability to have children: XPOVIO may affect the ability of both women and men to have children. Talk to your healthcare provider if you have concerns about fertility.
Females who are able to become pregnant: Your healthcare provider will check to see if you are pregnant before you start taking XPOVIO. You should use effective birth control (contraception) during treatment with XPOVIO and for 1 week after your last dose, as XPOVIO can harm an unborn baby. Tell your healthcare provider right away if you become pregnant or think you might be pregnant during treatment with XPOVIO. Do not breastfeed during treatment with XPOVIO and for 1 week after your last dose of XPOVIO. It is not known if XPOVIO passes into your breast milk.
Males with female partners who are able to become pregnant should use effective birth control during treatment with XPOVIO and for 1 week after your last dose.
Please see the Medication Guide for XPOVIO. See full Prescribing Information.
To report SUSPECTED ADVERSE REACTIONS, contact Karyopharm Therapeutics Inc. at 1‑888‑209‑93261‑888‑209‑9326 or FDA at 1‑800‑FDA‑10881‑800‑FDA‑1088 or www.fda.gov/medwatch.