What are the possible side effects with XPOVIO® (selinexor) + dexamethasone?

    Serious side effects
    • Low platelet counts
    • Low white blood cell counts
    • Nausea and vomiting
    • Diarrhea
    • Loss of appetite and weight loss
    • Decreased sodium levels in your blood
    • Infections
    • Neurologic side effects
    Common side effects
    • Tiredness
    • Low red blood cell count (anemia). Symptoms may include tiredness and shortness of breath
    • Constipation
    • Shortness of breath
    • Increased blood sugar
    • Changes in body salt and mineral levels in your blood
    • Changes in kidney and liver function blood tests

    These are not all the possible side effects of XPOVIO.
    Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1‑800‑FDA‑10881-800-FDA-1088 or fda.gov/medwatch

    Support Starts Here

    The XPOVIO Patient Education Starter Kit has helpful information about treatment as well as tips for living well with relapsed
    or refractory multiple myeloma (RRMM).

    Request Your Kit

    Request Your Kit

    What is XPOVIO?

    XPOVIO® (selinexor) is a prescription medicine used:

    • in combination with dexamethasone to treat adults with multiple myeloma (MM) that has come back (relapsed) or that did not respond to previous treatment (refractory), and
      • who have received at least 4 prior therapies, and
      • whose disease did not respond (refractory) to at least 2 proteasome inhibitor medicines, at least 2 immunomodulatory agents, and an anti-CD38 monoclonal antibody medicine

    What is the most important information I should know about XPOVIO?

    Your healthcare provider will do blood tests before you start taking XPOVIO, and often during the first 3 months of treatment, and then as needed during treatment to monitor you for side ef‍fects. Your healthcare provider may change your dose of XPOVIO, stop your treatment for a period of time, or completely stop your treatment if you have certain side ef‍fects during treatment with XPOVIO.