How do I take XPOVIO® (selinexor) + dexamethasone?

    The recommended dose is 80 mg (four 20-mg tablets) of XPOVIO and 20 mg of dexamethasone taken by mouth on Days 1 and 3 of each week, or as directed by your healthcare provider.

    Days 1 and 3 depend on which day of the week you start XPOVIO. For example, if you start XPOVIO on Tuesday, Tuesday is Day 1 and Thursday is Day 3.

    How to determine days 1 and 3 in the XPOVIO dosing schedule
    How to determine days 1 and 3 in the XPOVIO dosing schedule
    During treatment, your healthcare provider may change your dose of XPOVIO.
    Always take XPOVIO exactly as prescribed

    Keep Track

    Use the convenient Patient Daily Tracker to keep track of your medication as well as your fluid and caloric intake.

    Download Tracker

    What are the different dosing options for XPOVIO?

    The recommended dose is 80 mg (four 20-mg tablets) of XPOVIO and 20 mg of dexamethasone taken by mouth on Days 1 and 3 of each week. However, your healthcare provider may choose to modify your dose. Always follow the directions of your prescribing physician.

    Refer to the images below for more information on how your medicine is supplied.

    Recommended Dose

    XPOVIO® (selinexor) 80 mg twice weekly dose packaging

    80 mg — Twice Weekly dose

    Carton contents:
    4 medicine packages (32 tablets total in each carton)

    Tablets per package:
    Each package contains 8 20-mg tablets
    This package includes 2 doses of XPOVIO

    Weekly dose:
    80 mg twice weekly (4 tablets are taken on Day 1 and the remaining 4 are taken on Day 3 of each week)

    XPOVIO® (selinexor) 100 mg once weekly dose packaging

    100 mg — Once Weekly dose

    Carton contents:
    4 medicine packages (20 tablets total in the carton)

    Tablets per package:
    Each package contains 5 20-mg tablets
    This package includes 1 dose of XPOVIO

    Weekly dose:
    100 mg once weekly (5 tablets are taken on Day 1 of each week)

    XPOVIO® (selinexor) 80 mg once weekly dose packaging

    80 mg — Once Weekly dose

    Carton contents:
    4 medicine packages (16 tablets total in the carton)

    Tablets per package:
    Each package contains 4 20-mg tablets
    This package includes 1 dose of XPOVIO

    Weekly dose:
    80 mg once weekly (4 tablets are taken on Day 1 of each week)

    XPOVIO® (selinexor) 60 mg once weekly dose packaging

    60 mg — Once Weekly dose

    Carton contents:
    4 medicine packages (12 tablets total in each carton)

    Tablets per package:
    Each package contains 3 20-mg tablets
    This package includes 1 dose of XPOVIO

    Weekly dose:
    60 mg once weekly (3 tablets are taken on Day 1 of each week)

    What else should I know about taking XPOVIO + dexamethasone?

    Healthcare provider icon

    Talk to your healthcare provider before you change your dose or stop taking XPOVIO

    Do not crush icon

    Swallow XPOVIO whole with water. Never break, chew, crush, or divide the tablets

    Other medicines icon

    Take any medicines your healthcare provider prescribes for nausea/vomiting before and during treatment with XPOVIO

    Tell your doctor icon

    Tell your healthcare provider if the medicines don’t help with nausea/vomiting

    Glass of water icon

    Drink enough fluids during treatment to prevent dehydration

    Food icon

    Eat enough calories to prevent weight loss during treatment

    Schedule icon

    If you miss a dose of XPOVIO, take your next dose at your next regularly scheduled day and time

    Dosing icon

    If you vomit after taking a dose of XPOVIO, do not take an extra dose. Take your next dose at your next regularly scheduled day and time

    Call your healthcare provider icon

    If you take too much XPOVIO, call your healthcare provider right away

    Do not share icon

    Do not share your XPOVIO prescription with other people

    Blood test icon

    The healthcare provider will do blood tests before you start taking XPOVIO, more often during the first 3 months of treatment, and then as needed

    Checkmark icon

    Always ask your healthcare provider any questions you may have about treatment with XPOVIO

    What should I ask my healthcare team before starting XPOVIO?

    Before starting any treatment, it’s good to have an open and honest conversation with your healthcare provider. Here are a few questions that may help you discuss starting XPOVIO.

    1. Which anti-nausea medicines will I take prior to treatment with XPOVIO?
    2. How often will I need a blood test while taking XPOVIO?
    3. How do I ensure I stay hydrated while taking XPOVIO?
    4. Should I expect to lose weight while taking XPOVIO? If so, how much?
    5. Will my dose be changed throughout treatment with XPOVIO?
    6. How will my side effects be managed?
    7. What should I do if I have a new side effect or symptom?
    8. What should I know if I’m taking other medications?

    What is XPOVIO?

    XPOVIO® (selinexor) is a prescription medicine used:

    • in combination with dexamethasone to treat adults with multiple myeloma (MM) that has come back (relapsed) or that did not respond to previous treatment (refractory), and
      • who have received at least 4 prior therapies, and
      • whose disease did not respond (refractory) to at least 2 proteasome inhibitor medicines, at least 2 immunomodulatory agents, and an anti-CD38 monoclonal antibody medicine

    What is the most important information I should know about XPOVIO?

    Your healthcare provider will do blood tests before you start taking XPOVIO, and often during the first 3 months of treatment, and then as needed during treatment to monitor you for side ef‍fects. Your healthcare provider may change your dose of XPOVIO, stop your treatment for a period of time, or completely stop your treatment if you have certain side ef‍fects during treatment with XPOVIO.