Why XPOVIO® (selinexor)?

    XPOVIO is the only FDA-approved medicine of its kind that can treat relapsed refractory multiple myeloma (RRMM) when it has stopped responding to other types of treatment (lenalidomide, pomalidomide, bortezomib, carfilzomib, and daratumumab).

    XPOVIO is taken orally and travels through the body to fight RRMM
    Human body icon Human body icon
    Works when other
    treatments don’t
    You may respond to treatment with XPOVIO even if common treatments no longer work for you
    Kills at the cell core
    XPOVIO works at the core of the cell (the nucleus) to kill some cancer cells

    Selinexor + dexamethasone is included in the National Comprehensive Cancer Network Guidelines® (NCCN 
    Guidelines®) as category 2A

    for patients who have had at least 4 prior therapies and whose disease is refractory — or nonresponsive — to at least 2 PI treatments, at least 2 IMiD treatments, and an anti-CD38 mAb treatment*

    IMiD=immune-mediated inflammatory disease; mAb=monoclonal antibody;
    PI=proteasome inhibitor.

    *Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Multiple Myeloma. V.2.2020. © 2020 National Comprehensive Cancer Network, Inc. All rights reserved. Accessed November 26, 2019. To view the most recent and complete version of the NCCN Guidelines, go online to NCCN.org. NCCN makes no warranties of any kind whatsoever regarding their content, use or application and disclaims any responsibility for their application or use in any way.

    What is XPO1 and how does it work in healthy cells?

    Labeled image of XPO1 in a healthy cell

    For illustrative purposes only.

    Healthy cells

    Healthy cells have a protein called XPO1 that is responsible for carrying important materials in and out of the core of the cell (the nucleus). Many of these materials can help fight cancer, but only when they are inside the nucleus.

    How does XPOVIO work to block XPO1?

    Annotated diagram showing a cell with too much XPO1 Annotated diagram showing a cell with too much XPO1
    Annotated diagram showing XPOVIO® (selinexor) mechanism of action

    For illustrative purposes only.

    What is relapsed refractory multiple myeloma?

    Multiple myeloma is a cancer of the plasma cells, a type of white blood cell in the bone marrow

    If you’ve been living with multiple myeloma for some time now, you probably know a lot about the disease. You’ve been through periods of disease remission and relapse, and you may be refractory to some treatments.

    Multiple myeloma

    • These cancerous cells make copies in the bone marrow
    • When too many copies of the cancerous cells are present, it can lead to damage in the body and symptoms can increase over time

    Annotated diagram showing multiple myeloma cells in a bone

    For illustrative purposes only.

    Adapted from illustration created for the National
    Cancer Institute.
    © 2014 Terese Winslow LLC.

    Over time, multiple myeloma may become refractory to many different types of treatments. When this happens, your healthcare provider may start you on another type of treatment

    Remission
    The disease has responded to treatment. Your lab tests show improvement, and symptoms get better or go away
    Relapse
    The disease is once again active, and symptoms may return
    Refractory
    The disease does not respond to a treatment or you relapse
    within 60 days of stopping the treatment

    Relapsed refractory multiple myeloma can be challenging to treat when the disease has stopped responding to multiple types of therapies

    See Clinical Trial Outcome