XPOVIO (Selinexor). Restore your own cancer defenses

    NEW INDICATION: XPOVIO® (selinexor) targets multiple myeloma (MM) by helping to restore your body’s own tumor defense system, leading to cancer cell death.

    XPOVIO is now available for adult patients with MM who have received at least one prior therapy in combination with other treatments (bortezomib and dexamethasone)

    See clinical trial results

    XPOVIO® (selinexor) is the only FDA-approved oral medicine of its kind

    This XPOVIO + Velcade® (bortezomib) and dexamethasone (Vd) treatment regimen is a combination of 3 different medicines that work together to kill certain cancer cells.

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    Works differently:

    This XPOVIO + Vd treatment regimen is a combination of 3 different medicines that work together to kill certain cancer cells.

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    Treatment response:

    In a clinical study, more patients responded to treatment while taking XPOVIO + Vd compared with Vd alone (76% vs 62%, respectively).

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    Manageable side effects:

    The side effects of XPOVIO are generally manageable and/or reversible with appropriate care.

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    Taken at home:

    XPOVIO is a once-weekly pill that you take orally (by mouth) at home.

    How well did patients with multiple myeloma (MM) respond to the XPOVIO treatment regimen?

    In a study called the BOSTON trial, patients who had at least one prior treatment for their MM were studied. A combination of 3 therapies was given to treat their MM: XPOVIO and Velcade® (bortezomib) + dexamethasone (Vd).

    XPOVIO + Vd helped patients live longer without their cancer getting worse

    Progression free survival This means that 50% of the patients taking XPOVIO + Vd lived at least 14 months without their cancer getting worse.

    How many patients responded to the XPOVIO treatment regimen?

    More patients responded to XPOVIO + Vd than Vd alone

    Response rate

    About XPOVIO® (selinexor)

    What is XPO1 and why does it matter?

    • Healthy cells have a protein called XPO1 that is responsible for carrying important materials in and out of the core of the cell (the nucleus)
    • Many of these materials help fight cancer, but only when they are inside the nucleus
    Diagram of a cell

    XPOVIO helps to restore the body’s own tumor defense system by blocking XPO1

    Diagram of how XPOVIO works

    See the video below for how XPOVIO works.

    Video about how XPOVIO works

    What are possible side effects of XPOVIO® (selinexor)?

    XPOVIO has a well-established safety profile. Side effects are generally manageable and/or reversible with appropriate care.

    XPOVIO may cause serious side effects, including:

    Low platelet counts

    Low white blood cell counts

    Serious infections

    Neurological side effects

    Nausea and vomiting


    Loss of appetite and weight loss

    Decreased sodium levels in your blood

    New or worsening cataract, cloudiness or loss of transparency in the lens of the eye

    Common side effects of XPOVIO include:



    Low red blood cell count (anemia)


    Shortness of breath

    Increased blood sugar

    Changes in body salt and mineral levels in your blood

    Changes in kidney and liver function blood tests

    These are not all of the possible side effects of XPOVIO. Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

    How do I take XPOVIO® (selinexor)?

    XPOVIO is a pill you take orally (by mouth). The recommended dose is 100 mg once per week.

    Diagram of the XPOVIO once weekly dosing schedule


    • When you take the XPOVIO treatment regimen (3 medicines), you will take each medication as prescribed throughout this week
    • Your healthcare provider may prescribe additional medicines to help prevent nausea/vomiting during treatment with XPOVIO
    • Take your medications as prescribed by your healthcare provider and be sure to let them know how you are feeling along the way

    What else should I know about taking XPOVIO?

    • Talk to your healthcare provider before you change your dose or stop taking XPOVIO
    • Swallow XPOVIO whole with water. Never break, chew, crush, or divide the tablet
    • Take any medicines your healthcare provider prescribes for nausea/vomiting before and during treatment with XPOVIO
    • Tell your healthcare provider if the medicines don’t help with nausea/vomiting
    • Drink enough fluids during treatment to prevent dehydration
    • Eat enough calories to prevent weight loss during treatment
    • If you miss a dose of XPOVIO, take your next dose at your next regularly scheduled day and time
    • If you vomit after taking a dose of XPOVIO, do not take an extra dose. Take your next dose at your next regularly scheduled day and time
    • If you take too much XPOVIO, call your healthcare provider right away
    • Do not share your XPOVIO prescription with other people

    Your healthcare provider will do blood tests before you start taking XPOVIO, more often during the first 3 months of treatment, and then as needed.

    What should I ask my healthcare team before taking XPOVIO?

    • Which anti-nausea medicines will I take prior to treatment with XPOVIO?
    • How often will I need a blood test while taking XPOVIO?
    • How do I ensure I stay hydrated while taking XPOVIO?
    • Should I expect to lose weight while taking XPOVIO? How much?
    • Will my dose be changed throughout treatment with XPOVIO?
    • How will my side effects be managed?
    • What should I do if I have a new side effect or symptom?
    • What should I know if I’m taking other medications?


    What support and resources are available?

    KaryForward® is a patient support program by Karyopharm Therapeutics® Inc. dedicated to providing assistance and resources to you and your caregiver for XPOVIO® (selinexor).

    The KaryForward program is here to help you every step of the way during your treatment journey:

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    Insurance coverage*

    • Understand your benefits
    • File claims
    • Provide support during insurance appeals
    • Find out what is covered by your insurance
    • Access Karyopharm medications, even if there are unexpected delays or interruptions
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    Financial assistance

    • Qualify for the XPOVIO Copay Program and pay as little as $5 for each XPOVIO prescription, or
    • If eligible, get XPOVIO at no cost to you
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    Support and resources

    • Nurse Case Managers who can provide education, prescription instructions, and emotional and ongoing support
    • Referrals to additional third-party support, such as transportation assistance


    For Caregivers: How do I take care of myself when I’m caring for someone taking XPOVIO?

    The physical and emotional demands of being a caregiver can take a toll over time

    You may experience:

    • Exhaustion
    • Getting sick more often
    • Losing sleep
    • Irritation

    Tips for caring for yourself include:

    • Consider finding a support group online or in your local area, or connecting with people who understand what you may be going through
    • If you have questions or support needs, talk to the nurse, social worker, or your loved one’s healthcare provider
    • Consider practicing yoga or meditation to help relieve stress

    For Caregivers: What should I know about caring for someone taking XPOVIO?

    When caring for someone taking XPOVIO, keep in mind:

    • The dosing schedule for XPOVIO and anti-nausea medicines will be determined by the healthcare professional
    • Call the healthcare provider if your loved one experiences any new or worsening side effects
    • The healthcare team will do blood tests before your loved one starts taking XPOVIO, more often during the first 3 months of treatment, and then as needed
    • Encourage your loved one to drink lots of fluids and eat nutritious food while on XPOVIO

    Join the KaryForward Support Program and you and your loved ones will receive:

    • Helpful caregiver resources
    • XPOVIO Patient Education Starter Kit
    • Personalized support from Nurse Case Managers
    • Information about financial resources
    Enroll now

    Helpful tools and resources

    When caring for patients taking XPOVIO, keep in mind:

    Whether you’re living with multiple myeloma (MM) or supporting a loved one with MM, it’s important to remember that you’re not alone. There are a number of valuable resources and organizations available to help. Use the following materials and links to get the support you need and deserve.

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    Patient and Caregiver Brochure

    Get information about treatment
    with XPOVIO

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    KaryForward Enrollment Form

    Enroll in KaryForward, a patient
    support program


    What additional support is available for me?

    General Cancer Resources

    American Cancer Society www.cancer.org 800-227-2345 CancerCare www.cancercare.org 800-813-HOPE (4673)

    Caregiver Support Resources

    Caregiver Action Network www.caregiveraction.org 202-454-3970 Family Caregiver Alliance www.caregiver.org 800-445-8106

    MM Resources

    International Myeloma Foundation www.myeloma.org 800-452-CURE (2873) Leukemia & Lymphoma Society www.lls.org 800-955-4572
    Lymphoma Coalition www.lymphomacoalition.org Multiple Myeloma Research Foundation www.themmrf.org 866-603-MMCT (6628)

    To maintain the independence of these organizations, Karyopharm Therapeutics® Inc. does not endorse or recommend any of the advocacy groups or services on this list and is not responsible for the content of these sites or services. Be sure to speak with your loved one’s healthcare professional before making any changes to their treatment plan.

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    What is XPOVIO?

    XPOVIO® (selinexor) is a prescription medicine used:

    • in combination with bortezomib and dexamethasone (XVd) to treat adult
      patients with multiple myeloma who have received at least one prior

    Your healthcare provider will do blood tests before you start taking XPOVIO, and often during the first 3 months of treatment, and then as needed during treatment.

    XPOVIO can cause serious side effects, including:

    • Low platelet counts. Low platelet counts are common with XPOVIO and can lead to bleeding, which can be severe and can sometimes cause death.