How do I take XPOVIO® (selinexor)?
The recommended dosage of XPOVIO is 60 mg taken by mouth on Days 1 and 3 of each week.
- Days 1 and 3 depend on which day of the week you start XPOVIO. For example, if you start XPOVIO on Tuesday, Tuesday is Day 1 and Thursday is Day 3
- You don’t need to take XPOVIO with another anti-cancer medicine for relapsed or refractory diffuse large B-cell lymphoma (RR DLBCL)
- Your healthcare provider may prescribe medicines to help prevent nausea/vomiting during treatment with XPOVIO
- Take your medication as prescribed by your healthcare provider and be sure to let them know how you are feeling along the way
Always take XPOVIO exactly as prescribed
What are the different dosing options for XPOVIO?
The recommended dose is 60 mg (three 20-mg tablets) of XPOVIO taken by mouth on Days 1 and 3 of each week. However, your healthcare provider may choose to modify your dose. Always follow the directions of your prescribing physician.
Refer to the images below for more information on how your medicine is supplied.
NDC
NDC 72237-101-03
Contents
4 blister packs
(24 tablets total per carton)
Tablets per blister pack
Six
20-mg tablets
Weekly dose
60 mg
twice weekly
Carton
NDC
NDC 72237-102-06
Contents
4 weekly blister packs
(8 tablets total per carton)
Tablets per blister pack
Two
40-mg tablets
Weekly dose
40 mg
twice weekly
Carton
NDC
NDC 72237-104-01
Contents
4 weekly blister packs
(4 tablets total per carton)
Tablets per blister pack
One
60-mg tablet
Weekly dose
60 mg
once weekly
Carton
NDC
NDC 72237-102-07
Contents
4 weekly blister packs
(4 tablets total per carton)
Tablets per blister pack
One
40-mg tablet
Weekly dose
40 mg
once weekly
Carton
What else should I know about taking XPOVIO?
Talk to your healthcare provider before you change your dose or stop taking XPOVIO
Swallow XPOVIO whole with water. Never break, chew, crush, or divide the tablets
Take any medicines your healthcare provider prescribes for nausea/vomiting before and during treatment with XPOVIO
Tell your healthcare provider if the medicines don’t help with nausea/vomiting
Drink enough fluids during treatment to prevent dehydration
Eat enough calories to prevent weight loss during treatment
If you miss a dose of XPOVIO, take your next dose at your next regularly scheduled day and time
If you vomit after taking a dose of XPOVIO, do not take an extra dose. Take your next dose at your next regularly scheduled day and time
If you take too much XPOVIO, call your healthcare provider right away
Do not share your XPOVIO prescription with other people
Your healthcare provider will do blood tests before you start taking XPOVIO, more often during the first 3 months of treatment, and then as needed
Always ask your healthcare provider any questions
you may have about treatment with XPOVIO
What should I ask my healthcare team before starting XPOVIO?
Before starting any treatment, it’s good to have an open and honest conversation with your healthcare provider. Here are a few questions that may help you discuss starting XPOVIO.
- Which anti-nausea medicines will I take prior to treatment with XPOVIO?
- How often will I need a blood test while taking XPOVIO?
- How do I ensure I stay hydrated while taking XPOVIO?
- Should I expect to lose weight while taking XPOVIO? If so, how much?
- Will my dose be changed throughout treatment with XPOVIO?
- How will my side effects be managed?
- What should I do if I have a new side effect or symptom?
- What should I know if I’m taking other medications?
